[ \u30d2\u30c8\u03b2-\u30ac\u30e9\u30af\u30c8\u30b7\u30c0\u30fc\u30bc\u306e\u7acb\u4f53\u69cb\u9020\u4e88\u6e2c\u3068\u30a2\u30df\u30ce\u9178\u5909\u7570\u306b\u3088\u308b\u69cb\u9020\u5909\u5316\u306e\u89e3\u6790 ]
\n\u5e73\u77f3\u3055\u3093\u3002
\n\u69cb\u9020\u672a\u77e5\u9175\u7d20\u306e\u7acb\u4f53\u69cb\u9020\u3092\u4e88\u6e2c\u3002\u5909\u7570\u304c\u8d77\u304d\u305f\u5834\u5408\u306e\u5f71\u97ff\u3092\u4e88\u6e2c\u3002
\n\u30a2\u30aa\u30ab\u30d3\u306e\u3082\u306e\u306f\u69cb\u9020\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u304c\u30d2\u30c8\u306e\u306f\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u3002\u914d\u5217\u306f\u308f\u304b\u3063\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u4e21\u8005\u306e\u914d\u5217\u306e\u985e\u4f3c\u6027\u306f 20% \u304f\u3089\u3044\u3067\u3001\u30db\u30e2\u30ed\u30b8\u30fc\u30e2\u30c7\u30ea\u30f3\u30b0\u306f\u4f7f\u3048\u306a\u3044\u3002\u3067\u3001\u76f4\u63a5\u914d\u5217\u3092\u6bd4\u8f03\u3059\u308b\u3002
\n3D-1D \u6cd5\u3002
\n\u592a\u7530\u5148\u751f: \u4e88\u60f3\u3057\u305f\u69cb\u9020\u306e\u306a\u304b\u3067\u57fa\u8cea\u304c\u3053\u3053\u306b\u7d50\u5408\u3059\u308b\u3060\u308d\u3046\u3068\u304b\u3001\u3053\u3046\u3044\u3046\u4f5c\u7528\u3092\u3059\u308b\u3060\u308d\u3046\u3068\u304b\u3001\u305d\u3046\u3044\u3046\u3053\u3068\u306f\u898b\u3048\u308b\uff1f
\n\u2192 \u914d\u5217\u304c\u9055\u3063\u3066\u3082\u7acb\u4f53\u69cb\u9020\u306f\u306b\u3066\u3044\u308b\u3001\u3068\u3044\u3046\u306e\u306f\u591a\u3044\u306e\u3067\u3001\u6d3b\u6027\u90e8\u4f4d\u306e\u69cb\u9020\u306b\u95a2\u3059\u308b\u77e5\u898b\u3068\u3042\u308f\u305b\u3066\u3001\u3046\u307e\u304f\u4f7f\u3063\u3066\u3044\u304f\u3053\u3068\u306f\u3067\u304d\u308b\u304b\u3082\u3002
\n\u5ca1\u5148\u751f: 3D-1D \u3067\u4e88\u6e2c\u306f\u3067\u304d\u308b\u304c\u3001\u4e88\u6e2c\u7d50\u679c\u304c\u6b63\u3057\u3044\u304b\u3069\u3046\u304b\u306f\u3069\u3046\u3084\u3063\u3066\u30c1\u30a7\u30c3\u30af\u3059\u308b\u306e\u304b\uff1f
\n\u2192\u3000\u30db\u30e2\u30ed\u30b8\u30fc\u30e2\u30c7\u30ea\u30f3\u30b0\u304c\u9069\u7528\u3067\u304d\u306a\u3044\u306e\u3067\u3053\u3046\u3057\u305f\u308f\u3051\u3067\u3059\u304c\u3001\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u914d\u5217\u3092\u4f7f\u3063\u3066\u90e8\u5206\u3054\u3068\u306b\u30c1\u30a7\u30c3\u30af\u3057\u3066\u3044\u308b\u304b\u3089\u5927\u4e08\u592b (?) \u3067\u3001\u3044\u3044\u3067\u3059\u304b\uff1f
\n\u5909\u52d5\u306e\u5024\u306f\u306a\u306b\uff1f
\n\u2192 \u5909\u52d5\u3059\u308b x-y-z \u306e\u5ea7\u6a19\u4f4d\u7f6e\u306e\u81ea\u4e57\u3092\u8db3\u3057\u305f\u3082\u306e
\n\u3053\u306e\u65b9\u6cd5\u3060\u30683\u6b21\u5143\u7684\u306a\u4f4d\u7f6e\u304c\u7279\u5b9a\u3067\u304d\u308b\uff1f
\n\u2192 \u306f\u3044
\n\u661f\u5148\u751f: \u592a\u7530\u5148\u751f\u306e\u3068\u306e\u3084\u308a\u3068\u308a\u3067\u3059\u304c\u3001\u3061\u3087\u3063\u3068\u304b\u308f\u3063\u305f\u3060\u3051\u3067\u6d3b\u6027\u90e8\u4f4d\u306e\u50cd\u304d\u304c\u5927\u304d\u304f\u5909\u308f\u3063\u3061\u3083\u3046\u3053\u3068\u306f\u3042\u308a\u307e\u3059\u3088\u30fc\u3002
\n[ \u4f4d\u7f6e\u7279\u7570\u7684\u30b9\u30b3\u30a2\u884c\u5217\u3092\u7528\u3044\u305f\u6a5f\u80fd\u6027 RNA \u63a2\u7d22\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306e\u958b\u767a ]
\n\u68ee\u7530\u3055\u3093\u3002
\n\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306a\u3089\u306a\u3044 non-coding RNA (\u8ee2\u5199\u9818\u57df\u306e 98%) \u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u6a5f\u80fd\u6027 RNA\u3002
\n\u30e2\u30c1\u30fc\u30d5\u914d\u5217\u3068 2\u6b21\u69cb\u9020\u3060\u3051\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u5834\u5408\u304c\u3042\u308b\u304c\u3001\u3053\u306e\u5834\u5408\u306f\u6a5f\u80fd\u304c\u308f\u304b\u3089\u306a\u3044\u3002
\nPHMMTS = stem & loop \u306a\u3084\u3064\u3068\u304b\u30012\u6b21\u69cb\u9020\u4ed8\u304dRNA\u914d\u5217\u306e\u63a2\u7d22\u3092\u3059\u308b\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\uff08\u698a\u539f\u5148\u751f\u304c\u63d0\u6848\u3057\u305f\u3084\u3064\u3060\uff09
\n\u63d0\u6848\u3057\u305f\u306e\u306f Position Specific Score Matrix on Tree Structures (PSSMTS):\u3000RNA \u914d\u5217\u30682\u6b21\u69cb\u9020\u30e2\u30c1\u30fc\u30d5\u304b\u3089\u30a2\u30e9\u30a4\u30e1\u30f3\u30c8\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u3053\u308c\u306b\u3088\u3063\u3066\u3001\u30e2\u30c1\u30fc\u30d5\u914d\u5217\u3092\u4f7f\u3063\u305f\u691c\u7d22\u304c\u3067\u304d\u308b\u3002
\n\u30a4\u30f3\u30c8\u30ed\u30f3\u9818\u57df\u306b\u3053\u3046\u3044\u3046\u914d\u5217\u304c\u304a\u304a\u3044\u306e\u3067\u3001\u305d\u3046\u3044\u3046\u77e5\u898b\u3092\u3044\u304b\u3057\u3066\u691c\u7d22\u306e\u5bfe\u8c61\u9818\u57df\u3092\u524a\u6e1b\u3057\u305f\u308a\u3068\u304b\u3001\u305d\u3093\u306a\u3053\u3068\u3082\u8003\u3048\u3066\u3044\u304d\u305f\u3044\u3068\u601d\u3063\u3066\u304a\u308a\u307e\u3059\u3067\u3059\u3088\u3002
\n\u67f3\u5ddd\u5148\u751f: \u7dda\u866b\u306e\u914d\u5217\u304b\u3089\u307f\u3064\u3051\u305f orfan snoRNA \u306f exon \u9818\u57df\u306e\u3082\u306e\u304b intron \u9818\u57df\u306e\u3082\u306e\u304b\u3068\u304b\u3001\u306f\u307e\u3060\u8abf\u3079\u3066\u306a\u3044\u306e\u306d\uff1f (\u5168\u914d\u5217\u304b\u3089\u691c\u7d22\u3057\u3061\u3083\u3063\u3066\u308b\u3093\u3060\u3088\u306d\uff1f\uff09
\n\u2192 \u306f\u3044\u3001\u3053\u308c\u304b\u3089\u8abf\u3079\u307e\u3059\u3002
\nintron \u306b\u9650\u5b9a\u3057\u3066\u4f5c\u696d\u59cb\u3081\u308b\u524d\u306b\u3001\u4eca\u56de\u898b\u3064\u3051\u305f\u30e2\u30ce\u304c\u5168\u90e8 intron \u306a\u306e\u304b\u3001\u3068\u304b\u8abf\u3079\u306a\u3044\u306e\uff1f
\n\u2192 \u3084\u308a\u307e\u3059\u3084\u308a\u307e\u3059\u3002
\n\u5ca1\u5148\u751f: \u7dda\u866b\u306e\u3067\u3001\u5b66\u7fd2\u306b\u7528\u3044\u305f\u914d\u5217\u304c\u30a4\u30de\u30a4\u30c1\u3060\u3063\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u304c\u3001\u3053\u308c\u3001\u3044\u3044\u914d\u5217\u3092\u4f7f\u3048\u3070\u7d50\u679c\u306f\u826f\u304f\u306a\u308b\uff1f
\n\u2192 \u305d\u306e\u306f\u305a\u3067\u3059
\n\u3093\u3058\u3083\u305d\u308c\u3082\u3044\u3063\u3057\u3087\u306b\u306e\u3063\u3051\u308b\u3068\u3044\u3044\u306d\u3002
\n[ \u591a\u56e0\u5b50\u907a\u4f1d\u6027\u75be\u60a3\u306b\u95a2\u308f\u308b SNP \u306e… ]
\n\u304a\u540d\u524d\u5931\u5ff5\u3002
\n\u5358\u56e0\u5b50\u75be\u60a3\u306b\u3064\u3044\u3066\u306f\u306a\u3093\u3068\u304b\u308f\u304b\u3063\u3066\u304d\u3066\u3044\u308b\u3002
\n\u591a\u56e0\u5b50\u75be\u60a3\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u306a\u3093\u3068\u3082\u3002\u907a\u4f1d\u7684\u8981\u56e0\u3068\u304b\u751f\u6d3b\u7fd2\u6163\u3068\u304b\u3002
\nDNA \u591a\u578b: \u53cd\u5fa9\u914d\u5217\u3001\u633f\u5165\u30fb\u6b20\u5931\u3001\u4e00\u5869\u57fa\u591a\u578b(SNP)
\nSNP \u3068\u3001\u75be\u60a3\u306e\u6709\u7121\u306e\u8868\u3092\u3064\u304f\u3063\u3066\u7dcf\u5f53\u305f\u308a\u3067\u8abf\u3079\u308b\u3068\u7d44\u307f\u5408\u308f\u305b\u7206\u767a\u3002
\n\u78ba\u5b9a\u6728\u6cd5\u3001\u3068\u3044\u3046\u306e\u304c\u65e2\u5b58\u306e\u8a08\u7b97\u91cf\u524a\u6e1b\u624b\u6cd5\u3060\u304c\u3001\u63a2\u7d22\u7bc4\u56f2\u304c\u72ed\u3044\u3002
\n\u632f\u52d5\u6728\u6cd5\u3001\u3068\u3044\u3046\u306e\u3092\u63d0\u6848\u3002\u74b0\u5883\u8981\u56e0 (\u6027\u5225\u3068\u55ab\u7159\u306a\u3069) \u3082\u5165\u529b\uff08\u5b66\u7fd2\u7528\uff09\u3068\u3057\u3066\u7528\u3044\u308b\u3002\u5206\u5c90\u5c5e\u6027\u56e0\u5b50\u3092\u78ba\u7387\u7684\u306b\u9078\u629e\u3059\u308b\u3053\u3068\u3067\u3001\u78ba\u5b9a\u6728\u6cd5\u306e\u6574\u6570\u500d\u306e\u8a08\u7b97\u91cf\u3067\u5e83\u3044\u63a2\u7d22\u7bc4\u56f2\u3092\u5f97\u3089\u308c\u308b\u3002
\n\u5ca1\u5148\u751f\uff1a \u632f\u52d5\u6728\u6cd5\u3068\u3044\u3046\u306e\u306f\u307e\u3063\u305f\u304f\u65b0\u3057\u3044?
\n\u2192 \u306f\u3044\u3001\u3053\u308c\u304c\u306f\u3058\u3081\u3066\u3067\u3059\u3002
\n\u4eca\u56de\u306e SNP \u306f\u305c\u3093\u3076\u30b3\u30fc\u30c9\u9818\u57df\u306e\u3082\u306e\uff1f
\n\u2192 (\u307b\u307c)\u5168\u90e8\u30b3\u30fc\u30c9\u9818\u57df\u306b\u3042\u308b\u3082\u306e\u3067\u3059\u3002\u5206\u5b50\u751f\u7269\u5b66\u7684\u306a\u77e5\u898b\u304b\u3089\u9ad8\u8840\u5727\u3060\u3068\u304b\u80a5\u6e80\u3060\u3068\u304b\u306b\u95a2\u9023\u304c\u6df1\u3044\u3068\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u3092\u3001\u533b\u5b66\u90e8\u306e\u5148\u751f\u304c\u63d0\u4f9b\u3057\u3066\u304f\u3060\u3055\u3063\u305f\u3002
\n\u305d\u3053\u3089\u3078\u3093\u306e\u3072\u3068\u306e\u767a\u8a00\u3092\u307f\u3066\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3068\u3089\u306a\u3044\u3068\u307e\u305a\u3044\u3088\u30fc\u3001\u3068\u304b\u3044\u3046\u5224\u5b9a\u306b\u4f7f\u3048\u308b\uff1f
\n\u2192 \u3055\u304d\u306b\u75c7\u72b6\u304c\u51fa\u3066\u308b\u4eba\u3092\u307f\u305f\u30c7\u30fc\u30bf\u3067\u3084\u3063\u3066\u308b\u306e\u3067\u3001\u307e\u3060\u305d\u308c\u306f\u30c0\u30e1\u3060\u3068\u601d\u3044\u307e\u3059\u3002
\n[ \u30d0\u30af\u30c6\u30ea\u30a2\u3092\u7528\u3044\u305f\u4e26\u5217\u5206\u5b50\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u306e\u958b\u767a ]
\n\u4e2d\u5cf6\u3055\u3093\u3002
\n\u5148\u884c\u7814\u7a76\u3067\u6709\u9650\u30aa\u30fc\u30c8\u30de\u30c8\u30f3\u3092 DNA \u3067\u4f5c\u3063\u305f\u306e\u3067\u3001\u30bb\u30eb\u30aa\u30fc\u30c8\u30de\u30c8\u30f3\u306b\u62e1\u5f35\u3059\u308b\u8a66\u307f\u3002
\n\u8a08\u7b97\u7d20\u5b50\u306f DNA \u3067\u3001\u5165\u51fa\u529b\u306f\u751f\u4f53\u5206\u5b50\u3002
\n\u30d0\u30af\u30c6\u30ea\u30a21\u500b\u4f53\u304c\u30aa\u30fc\u30c8\u30de\u30c8\u30f3\u3002\u30b3\u30ed\u30cb\u30fc\u3067\u30bb\u30eb\u30aa\u30fc\u30c8\u30de\u30c8\u30f3\u3092\u69cb\u6210\u3002
\nAHL (Acetyl-Homoserine Lactone): \u4f4e\u5206\u5b50\u306e\u305f\u3081\u7d30\u80de\u58c1\u3092\u901a\u904e\u3067\u304d\u308b\u3002\u3053\u308c\u3092\u30b7\u30b0\u30ca\u30eb\u3068\u3057\u3066\u7528\u3044\u308b\u3002
\n\u53d7\u4fe1\u30d0\u30af\u30c6\u30ea\u30a2\u3092\u5b9f\u73fe\u3002
\n\u53d7\u4fe1\u30d0\u30af\u30c6\u30ea\u30a2\u3092\u57f9\u990a\u3057\u3066\u4e2d\u5fc3\u306b\u9001\u4fe1\u30d0\u30af\u30c6\u30ea\u30a2\u3092\u52a0\u3048\u308b\u3068\u4e2d\u592e\u304b\u3089\u3061\u3083\u3093\u3068\u4f1d\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3067\u304d\u305f\u3002
\n\u9001\u53d7\u4fe1\u306e\u4e21\u65b9\u3092\u5c0e\u5165\u3057\u305f E.coli = AHL \u3092\u52a0\u3048\u306a\u304f\u3066\u3082 GFP \u304c\u767a\u73fe\u3057\u3061\u3083\u3063\u305f\u3002
\n\u5bfe\u7b56\u306f\u3044\u307e\u3084\u3063\u3066\u307e\u3059\u3002
\n\u5ca1\u5148\u751f\uff1a \u81ea\u5206\u304b\u3089\u51fa\u3059\u3084\u3064\u306b\u81ea\u5206\u3067\u53cd\u5fdc\u3057\u3061\u3083\u3046\u3053\u3068\u306f\u306a\u3044\uff1f Deterministic automata \u306b\u3057\u3088\u3046\u3068\u3059\u308b\u3068\u3001\u30ce\u30a4\u30ba\u306e\u5f71\u97ff\u3067\u306e\u78ba\u7387\u7684\u6319\u52d5\u306e\u5f71\u97ff\u304c\u5927\u304d\u3044\u3068\u601d\u3046\u3093\u3060\u3051\u3069\u3001\u3069\u3046\u3067\u3057\u3087\u3046\u306a\u3002
\n\u2192 \u611f\u5ea6\u3092\u4e0b\u3052\u308b\u3053\u3068\u3067\u5916\u304b\u3089\u304f\u308b\u3084\u3064\u3057\u304b\u53cd\u5fdc\u3057\u306a\u304f\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3002\u78ba\u7387\u7684\u306a\u6319\u52d5\u306e\u90e8\u5206\u306b\u3064\u3044\u3066\u306f\u4f55\u3068\u304b\u3002
\n\u683c\u5b50\u72b6\u306b\u30bb\u30eb\u304c\u4e26\u3093\u3067\u3044\u306a\u3044\u3068\u30c0\u30e1\u3058\u3083\u306a\u3044\u304b\u3068\u601d\u3046\u3093\u3067\u3059\u304c
\n\u2192 \u306f\u3044\u3001\u305d\u306e\u901a\u308a\u3067\u3001\u8a08\u7b97\u30e2\u30c7\u30eb\u304b\u3089\u8003\u3048\u306a\u3044\u3068\u3044\u3051\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u3002
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